XB-FEAT-5843935

unnamed

This is the community wiki page for the gene unnamed please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.

nomenclature changes

16MAY2023

Xenopus gene name changed from XB5843935 [provisional:kctd12], provisional ortholog of potassium channel tetramerization domain containing 12 to kctd12l, potassium channel tetramerization domain containing 12

synteny & orthology

16MAY2023

Synteny does NOT support this gene as the true ortholog of the human KCTD12, so we will provisionally call it a like gene:

Human chr13: MYCBP2> FBXL3> CLN5> ACOD>1 KCTD12< LMO7< UCHL3< COMMD6> TBC1D4>

XTROPCHR8: cmc4> dkc1> rbmx2< loc< loc< XB5843935>(run through) znf5354

Mouse: Slc25a14> Gpr119> Rbmx2> Gm7770> Fsip2l< Enox2< Arhgap36> Or11q2

orthogy

DIOPT/EggNog analaysis of the Xtrop protein [XP_017951589.1] matches it with > 1700 proteins in >200 species as a KDTD gene family.

Including these Mouse genes:Kctd4, Kctd14, Kctd19, Kctd12, Kctd7, Kctd16, Kctd15, Kcnrg, Kctd1, Kctd11, Kctd18, Kctd12b, Kctd6, Kctd21, Kctd8.

Further analaysi is required to best name this gene in Xenopus, so for now we will call it a Kctd12-like gene.

>XP_017951589.1 uncharacterized protein LOC100124783 isoform X1 [Xenopus tropicalis] MALADHTSCIRQGEELPPFPDIIELNVGGQVYITRYPTLVSVPGSLLSEMFSQRNSRPLARDSKGRYFLD RDGFLFRYVLDYMRDQQLVLPDHFPERLRLQREAEFFRLPELVKILAPKVSKQNSIGDDAFQSDSEEQSP NVEVARNLASVSAALAAAAGNQSTMSDLRRSGFITIGYRGSYTLGRDSQTDAKFRRVARIMVCGKTSLAK EVFGDTLNDSRDPDRPPERYTSRYYLKFTFLEQAFDRLADAGFHMVACNSTGTCAFAHDQTDDKIWTSYT EYVFYRE