XB-FEAT-5846708

nucb1l

This is the community wiki page for the gene nucb1l please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase

nomenclature changes

05JUNE2023 Xenopus gene name changed from uncharacterized protein LOC108713706/XB5846708 [provisional] to nucb1l, nucleobindin 1 like

characterization of Xenopus laevis protein

uncharacterized protein LOC108713706 isoform X1 [Xenopus laevis] NCBI Reference Sequence: XP_041445583.1

>XP_041445583.1 uncharacterized protein LOC108713706 isoform X1 [Xenopus laevis] MGSLIVKQELATSWGPPKLICFLLISLSLPTTDCLKVVMSNTPIKSLKDQEVFVPCTFSDFSKEKLDLNL LSVHWIRKTLNGSDEVYLYVSGTHTPTRPGSYISDSEIIRGNVALHLPRVQFTDEGEYTCTVFYTPNKQW GHSTLQVSVQPTGSLQPPAGSVLIGTEKRVQCEANGFYPKDITIQWVKRLSETNCISLDKDSCTGDTSGN EDGTFNAINHLTISPSLEDDGRRYLCIIKHRSLENELKLNFTLSVTEPPHEYKTLIAALVGTFLGVLFLG LCYFLYWKFLKKEPPKLSPITGAEDLVHMNKATLSCLISEFRPKPIRITLCLQRNGGEEMEIDSWDSGTQ TVQSAKRGKQSEAIVLEEREGLLINGEANLPPAQRPLQVEMVIVITTSKFLISSCQCTIHITPDIEEDDG AELTVRVTHSALRLPDSVSCPLKVNGVKPKLSEIVSPPCIIRGEPLYLICDINGFKPKPLSITWLKLDFN GRETELLCWNRGTTSESEYSHQLCETNNEDQSNSFLSILTMKPTLQDHKATFICRTHHYATESRAEKNMQ MLVSVVPTMDPINRNHPILFVNETMEFFCKIHSFHPETLEVDWYRDDEHLSSHNGPALPDNNGLFYCSSR ITYTPCVRDIGKKFRCEVSHQSLQNPKCVFWKLKYLISEPSVSAIKCDPEVPECNQPATLSCTIEKLYPE KCTIQWYQRQKIIESTTNVIKKDPESELYTKNTEMQFIPTMSHHGVEFHVDITHKKKTIKRSFTMKLKDL PDVTEVTYNKEENKPGKPVTLTCQLIGCNAQHFTAQWQVGGAPIEKEMRAETQTGPDSVSFLLTLMPTAE HYGKLFTCLLRYKDLPQPIKKSIYLEQPLDIQN

DIOPT/EggNog orthology group analaysis matches the LOC108713706 protein to 495 proetins in >250 species with GO MF:positive regulation of testosterone secretion including these accessions for Mouse and rat:

Mus musculus 3 seqs 10090.ENSMUSP00000033096, 10090.ENSMUSP00000034522, 10090.ENSMUSP00000032895 Nucb1, Clmp, Nucb2

Rattus norvegicus 3 seqs 10116.ENSRNOP00000028390, 10116.ENSRNOP00000027753, 10116.ENSRNOP00000010607 Nucb1, Nucb2, Clmp

and these 7 seqs in Xenopus (Silurana) .ENSXETP00000048657, 8364.ENSXETP00000048663, 8364.ENSXETP00000045911, 8364.ENSXETP00000062600, 8364.ENSXETP00000002682, 8364.ENSXETP00000034980, 8364.ENSXETP00000062440 8364.ENSXETP00000048657, 8364.ENSXETP00000048663, nucb1, 8364.ENSXETP00000062600, clmp, nucb2, 8364.ENSXETP00000062440.

based solely on this quick analyis, we think we can safely update this gene name from 'uncharacterized' to Nucb1-like, and away further analsysi to charcterise it fully.