XB-FEAT-940811

nomenclature changes

18OCT23

Xenopus gene changed from MGC69520 , Novel 7 transmembrane receptor (rhodopsin family) protein to gpr4l.2, G protein-coupled receptor 4 like gene 2.

This change was motivated to replace the MGC# symbol with something more meaningful, and was based on lack of synteny to true grp4 (see below) and a DIOPT/EggNog analysis, which aligned the protein to GPR4 in ~100 other species with very high confidence and similarity.

Although on the same chromosome as true gpr4 gene, these 2 genes are not adjacent to true gpr4, and therefore are not considered as gpr4 duplicates ( in which case they could be named gpr4.2 and grp4.3), but will be provisionally called 'like' genes.

XB5959819 symbol changed to grp4l.1/gpr4l

MGC69520 symbol changed to grp4l.2

synteny

18OCT23

Note that true orthologs of GPR4 are flanked by elm1/2 and opa3 , while these grp4-like genes are flanked by shkbp1 and sptbn4.

Human: chr19: VASP> OPA3< GPR4< EML2< EML2-AS1>

ZFISH: CHR15: nova2> polr1g< gpr4< eml2< gipr>

Xtrop.chr8: fbxo46< gipr< eml1> gpr4> opa3>

Xtrop v10.chr8: shkbp1< XB5959819> MGC69520> sptbn4<

Annotation notes: XB5959819 and MGC69520 may end u/require merging as they seem to be partial/fragmented sequence accessions of the same gene. In this case, I still think the merged model should be grp4-like based on EggNog 5.0 analysis which matches both to the GRP4 protein tree.