XB-FEAT-481134

hes5

This is the community wiki page for the gene hes5 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.

nomenclature changes

esr1 stands for 'enhancer of split-related' protein 1 gene. the gene bank accession DQ096795 for ers1/hes5.1 is used in the Lamr and Kitner (2005) paper: XB-ART-1554, and R Blewitt. 2009 Bioscience Horizons 2(1):2231, https://doi.org/10.1093/biohorizons/hzp006.

note that the nomenclature changed from esr1 to hes5.1, hes family bHLH transcription factor 5 gene 1 in ~2010.

04.04.2024 gene symbol changed from hes5.1 to hes5, to match human and other orthologs, with hes5.1 being kept as a synonym.

summary for human HES5 from NCBI

This gene encodes a member of a family of basic helix-loop-helix transcriptional repressors. The protein product of this gene, which is activated downstream of the Notch pathway, regulates cell differentiation in multiple tissues. Disruptions in the normal expression of this gene have been associated with developmental diseases and cancer. [provided by RefSeq, Dec 2008]