XB-FEAT-998898

trpv4

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Functional roles and expression of TRPV4

Summary from PMID: 38354101 "Recent advances on the structure and the function relationships of the TRPV4 ion channel" from Tamara Rosenbaum's lab [Universidad Nacional Autónoma de México, Mexico] in 2024.

"When TRPV4 was discovered, it was initially named OSM-9 in the invertebrate C. elegans [58] and then VR-OAC [55], OTRPC4 [56], or VRL-2 [59] in vertebrates. Since then, our knowledge of its roles in physiology and advances in the details of its structure have come a long way. Activation of the TRPV4 channel translates into Ca2+ signals and, the responses vary depending on the cell type and tissue where it is expressed. TRPV4´s expression is widely distributed throughout the human body. It has been shown to be present in the cardiac, respiratory, urinary, muscle-skeletal, digestive, immune, endothelial, central, and peripheral nervous systems"

"For instance, TRPV4 is expressed in several cells of the respiratory system and functions by maintaining homeostasis of osmotic pressure. In the lungs, TRPV4 transduces several stimuli into Ca2+ signals and regulates the relaxation of the main pulmonary artery and the vasoconstriction of pulmonary circulation. Importantly, this channel plays an important function in preserving the integrity of the alveolar epithelial barrier (and skin barrier), where its activity can impact the severity of chronic asthma and, due to its sensitivity to mechanical forces, it can influence pulmonary injury induced by ventilators used to treat respiratory failure [79–81]. Activation of TRPV4 by mechanical forces also regulates the function of retinal cells such as ganglion cell soma-dendrite, microglia and Müller cells, suggesting that it plays roles in diseases like glaucoma and in the skeletal system where it is expressed in cells such as osteoblasts and chondrocytes, where it also participates in mechanotransduction [82]."

"As for the kidneys, TRPV4 is expressed in the distal convoluted tubule and in regions where transcellular osmotic gradients can develop, regulating osmotic balance by modifying water secretion in the kidney. In nephrons expressed in regions of the kidneys where there is no water permeability, TRPV4 contributes to the detection of osmotic stimuli and regulation of blood pressure in the presence of increased salt intake [55]. Interestingly, TRPV4’s activation has been suggested to influence the severity and progression of polycystic kidney disease (PKD) [83]."

See https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10868539/ for details of citations [##] in above passaes.