XB-FEAT-22065095

spn

This is the community wiki page for the gene spn please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.

summary for Human SPN from NCBI

SPN - sialophorin

This gene encodes a highly sialylated glycoprotein that functions in antigen-specific activation of T cells, and is found on the surface of thymocytes, T lymphocytes, monocytes, granulocytes, and some B lymphocytes. It contains a mucin-like extracellular domain, a transmembrane region and a carboxy-terminal intracellular region. The extracellular domain has a high proportion of serine and threonine residues, allowing extensive O-glycosylation, and has one potential N-glycosylation site, while the carboxy-terminal region has potential phosphorylation sites that may mediate transduction of activation signals. Different glycoforms of this protein have been described. In stimulated immune cells, proteolytic cleavage of the extracellular domain occurs in some cell types, releasing a soluble extracellular fragment. Defects in expression of this gene are associated with Wiskott-Aldrich syndrome. [provided by RefSeq, Sep 2017]

Nomenclature changes

30SEPT2024

‘’Xenopus‘’ gene name changed from ‘’spn like provisional ’ to ‘’sialophorin‘’, based on NCBI orthology assertions, as Xenopus genes follow human ortholog gene names and symbols.

annotation notes

30SEPT2024

Mouse and Rat orthologs added to the XB gene page. Note that this gene is conserved across most tetrapod genomes and is not found in fishes.