XB-FEAT-1009285

rhbg

This is the community wiki page for the gene rhbg please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase

nomenclature changes

04/22/ 2016

Human name has changed for Entrez Gene: 57127. From Rh family, B glycoprotein (gene/pseudogene) to Rh family B glycoprotein (gene/pseudogene).

Also referrded to as "Rhesus (Rh) glycoprotein type B".

Background

Source: Zhou et al 2026. https://doi.org/10.1113/JP288958

Chronic kidney disease (CKD) involves a loss of renal function over time (Maringhini & Zoccali, 2024). As CKD progresses, the ability of the kidneys to excrete the daily load of acids, predominately generated from metabolism, is impaired (Nagami & Hamm, 2017; Nagami & Kraut, 2022). This leads to the retention of hydrogen ions (H+) and eventually an associated decline in plasma pH, namely metabolic acidosis.

The kidneys respond to acidosis by increasing urinary excretion of total ammonia (NH3 and NH4+) and titratable acids. The excretory capacity for ammonia (50–67%) accounts for the major urinary acid excretion compared to titratable acids (33–50%) (Hamm et al., 2015). In the human kidney, total ammonia is generated predominantly in the proximal tubule by deamination of glutamine and secreted into the lumen, reabsorbed in the thick ascending limb of Henle's loop, and then secreted into the collecting duct. In the collecting duct, NH3/NH4+ is transported by two NH3/NH4+ transporters, RhBG and RhCG (Han et al., 2013; Quentin et al., 2003). RhBG, that is, Rhesus (Rh) glycoprotein type B, transports both forms of ammonia (NH3 and NH4+) (Nakhoul & Lee Hamm, 2013; Nakhoul et al., 2005, 2006; Nakhoul, Abdulnour-Nakhoul, Boulpaep, et al., 2010; Nakhoul, Abdulnour-Nakhoul, Schmidt, et al., 2010) at the basolateral membrane of α-intercalated cells and non-A, non-B cells (Han et al., 2013).