XB-FEAT-29093414

prh1l

This is the community wiki page for the gene prh1l please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.

nomenclature changes

13APr2026 Xenopus gene symbol was updated, from teh uninformative LOC116407831 to prh1l, following nomenclature rules, where teh frog gene name and symbol follow that of human. As this gene was already characterized as the 'proline-rich protein HaeIII subfamily 1-like', we used the PRH1 root and added the L for like suffix.

summary for human PRH1 from NCBI

This gene encodes a member of the heterogeneous family of proline-rich salivary glycoproteins. The encoded preproprotein undergoes proteolytic processing to generate one or more mature isoforms before secretion from the parotid and submandibular/sublingual glands. Multiple distinct alleles of this locus including the parotid isoelectric-focusing variant slow (PIF-s), the parotid acidic protein (Pa), and the double band slow (Db-s) isoforms have been characterized. The reference genome encodes the Db-s allele. Certain alleles of this gene are associated with susceptibility to dental caries. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12. Co-transcription of this gene with adjacent genes has been observed. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2015]