XB-FEAT-29098714

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Revision as of 20:42, 15 April 2026 by Xenbase (talk | contribs) (Created page with "=''mul1''= =nomenclature changes= 13APR2026 ''Xenopus'' gene name changed from ''LOC116412398, mitochondrial ubiquitin ligase activator of nfkb 1-like'' to ''mul1, mitochondrial E3 ubiquitin protein ligase 1'' following assessemtn by NCBi RefSeq curators. In looking at these loci, it is actually GeneID:116412398 (XB-GENE-29098715) which is the ortholog of human MUL1, not GeneID: 100487584 (XB-GENE-5884886). These two loci are in tail-to-tail configuration. The gen...")
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mul1

nomenclature changes

13APR2026

Xenopus gene name changed from LOC116412398, mitochondrial ubiquitin ligase activator of nfkb 1-like to mul1, mitochondrial E3 ubiquitin protein ligase 1 following assessemtn by NCBi RefSeq curators. 

In looking at these loci, it is actually GeneID:116412398 (XB-GENE-29098715) which is the ortholog of human MUL1, not GeneID: 100487584 (XB-GENE-5884886). 

These two loci are in tail-to-tail configuration. The genomic sequence of GeneID:116412398 (XB-GENE-29098715) supports a 350 aa protein that shares 60% identity (77% similarity) and aligns well across the entire human 349 aa protein. It is supported by transcripts such as CF783801.1 with strong RNA-seq and intron structure support. It is now being represented by NM_001445355.1, encoding the 350 aa protein.

This is in contrast to GeneID: 100487584 (XB-GENE-5884886), where the genome does not support the protein and has a corrected model XM_. This locus has no transcripts that align to the putative CDS and it is unclear if this locus actually represents a protein coding gene.
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