XB-FEAT-29088410

nomenclature updates

11MAY29026

Xenopus gene nomenclature was updated to follow the names of human orthologs as assessed by NCBI, changing from LOC101735259, T-cell surface glycoprotein CD3 delta chain to hcst, hematopoietic cell signal transducer.

summary fro human HCST from NCBI

This gene encodes a transmembrane signaling adaptor that contains a YxxM motif in its cytoplasmic domain. The encoded protein may form part of the immune recognition receptor complex with the C-type lectin-like receptor NKG2D. As part of this receptor complex, this protein may activate phosphatidylinositol 3-kinase dependent signaling pathways through its intracytoplasmic YxxM motif. This receptor complex may have a role in cell survival and proliferation by activation of NK and T cell responses.