XB-FEAT-992966

iba57

This is the community wiki page for the gene iba57 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase

nomenclature changes

08/03/2015 Human name has changed for Entrez Gene: 200205. From IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae) to IBA57 homolog, iron-sulfur cluster assembly

nomenclature changes

12/18/2017

Human name has changed for Entrez Gene: 200205. From IBA57 homolog, iron-sulfur cluster assembly to IBA57, iron-sulfur cluster assembly

NCBI Summary

The protein encoded by this gene localizes to the mitochondrion and is part of the iron-sulfur cluster assembly pathway. The encoded protein functions late in the biosynthesis of mitochondrial 4Fe-4S proteins. Defects in this gene have been associated with autosomal recessive spastic paraplegia-74 and with multiple mitochondrial dysfunctions syndrome-3. Two transcript variants encoding different isoforms have been found for this gene. The smaller isoform is not likely to be localized to the mitochondrion since it lacks the amino-terminal transit peptide. [provided by RefSeq, Jul 2015]