XB-FEAT-993074

selenow1

This is the community wiki page for the gene selenow1 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase

nomenclature changes

11/07/2016

Human symbol has changed for genepage ID: 993074 From sepw1 to SELENOW

Human symbol has changed for Entrez Gene: 6415. From SEPW1 to SELENOW

Human name has changed for Entrez Gene: 6415. From selenoprotein W, 1 to selenoprotein W

Mouse symbol has changed for Entrez Gene: 20364. From Sepw1 to Selenow

09/12/2017

correspondance from Bhanu Rajput, Ph. D. [Staff Scientist Reference Sequence Project NCBI/NLM/NIH] 2.) issue concerning selenow gene.

XB-GENE-993075 was previously associated with Entrez GeneID:100145402, which was withdrawn because it was based on a zebrafish transcript (BC160969.1) that was erroneously annotated as Xenopus tropicalis.

He moved XB-GENE-993075 and the official nomenclature (selenow, selenoprotein W) to GeneID:100485593, which now represents Xt selenow gene.

While reviewing this locus, he found another paralog of selenow (GeneID:101731107) on chromosome 3, which is restricted to fish and frog (PMID:22479358).

This 2nd locus needed official nomenclature, and will be known by symbol selenow2     with gene name selenoprotein W2 (see below).

To comply with Gladyshev et al.'s recommendation for naming paralogs with suffixes on the symbols (PMID:27645994, Table 3), he suggested the following nomenclature for the 2 paralogs:

current                     [[changes to > new symbol       new name]]

selenow (XB-GENE-993075) changed to >  selenow1     selenoprotein W1

new gene GeneID:101731107 changed to > selenow2     selenoprotein W2

ACTION BY XENBASE: 09/12/17

CHANGED name from SELENOW to SELENOW1 , as requested Submitted SELENOW2 data and requested a new gene page.

NEW GENE PAGE created : XB-GENEPAGE:22041594

7.01.2020 Note that this comes upin the Entrez gene report every month- do not change the name. The human ortholog to selenow1 is SELENOW, and there is no human ortholog to selenow2.

NCBI summary

Summary This gene encodes a selenoprotein containing a selenocysteine (Sec) residue, which is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is highly expressed in skeletal muscle and brain in mammals. It belongs to the SelWTH family, which possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif, suggesting a redox function for this gene. Studies in mouse show that this selenoprotein is involved in muscle growth and differentiation, and in the protection of neurons from oxidative stress during neuronal development. A paralog of this gene is found on chromosome 3 (GeneID:101731107). [provided by RefSeq, Aug 2017]