XB-FEAT-993641

bcl11b

This is the community wiki page for the gene bcl11b please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.

nomenclature changes

01/12/2016

Human name has changed for Entrez Gene: 64919. From B-cell CLL/lymphoma 11B (zinc finger protein) to B-cell CLL/lymphoma 11B.

12/18/2017

Human name has changed for Entrez Gene: 64919. From B-cell CLL/lymphoma 11B to B cell CLL/lymphoma 11B

NCBI Summary

This gene encodes a C2H2-type zinc finger protein and is closely related to BCL11A, a gene whose translocation may be associated with B-cell malignancies. Although the specific function of this gene has not been determined, the encoded protein is known to be a transcriptional repressor, and is regulated by the NURD nucleosome remodeling and histone deacetylase complex. Four alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Aug 2013]

In situ preparation note

The community submitted images from the Patient lab for this gene show embryos which have been cleared using a 2:1 preparation of benzyl benzoate and benzoic acid (BB:BA or BA:BB).