XB-FEAT-6257453

msl3

This is the community wiki page for the gene msl3 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.

nomenclature changes

05/29/2017

Human name has changed for Entrez Gene: 10943. From male-specific lethal 3 homolog (Drosophila) to MSL complex subunit 3

summary

This gene encodes a nuclear protein that is similar to the product of the Drosophila male-specific lethal-3 gene. The Drosophila protein plays a critical role in a dosage-compensation pathway, which equalizes X-linked gene expression in males and females. Thus, the human protein is thought to play a similar function in chromatin remodeling and transcriptional regulation, and it has been found as part of a complex that is responsible for histone H4 lysine-16 acetylation. This gene can undergo X inactivation. Alternative splicing results in multiple transcript variants. In Humans, related pseudogenes have been identified on chromosomes 2, 7 and 8. [provided by RefSeq, Jul 2010]