XB-FEAT-1005809

upf3a

This is the community wiki page for the gene upf3a please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.

nomenclature changes

05/21/2017 Human name has changed for Entrez Gene: 65110. From UPF3 regulator of nonsense transcripts homolog A (yeast) to UPF3A, regulator of nonsense mediated mRNA decay

summary from refseq

This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome 13. Two splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]