XB-FEAT-5882198

acsl4

This is the community wiki page for the gene acsl4 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase

nomenclature changes

06/19/2017 Human name has changed for Entrez Gene: 2181. From acyl-CoA synthetase long-chain family member 3 to acyl-CoA synthetase long chain family member 3

summary from NCBI

The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in brain, and preferentially utilizes myristate, arachidonate, and eicosapentaenoate as substrates. The amino acid sequence of this isozyme is 92% identical to that of rat homolog. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]