XB-FEAT-868116

tle5

This is the community wiki page for the gene tle5 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase

nomenclature changes

05.13.19

Human name has changed for Entrez Gene: 166. From amino-terminal enhancer of split to TLE family member 5, transcriptional modulator

Human symbol has changed for genepage ID: 868116 From aes to TLE5

Human symbol has changed for Entrez Gene: 166. From AES to TLE5

Zebrafish symbol has changed for Entrez Gene: 393395. From aes to tle5

Mouse symbol has changed for Entrez Gene: 14797. From Aes to Tle5

Summary from NCBI for human TLE5

The protein encoded by this gene is similar in sequence to the amino terminus of Drosophila enhancer of split groucho, a protein involved in neurogenesis during embryonic development. The encoded protein, which belongs to the groucho/TLE family of proteins, can function as a homooligomer or as a heteroologimer with other family members to dominantly repress the expression of other family member genes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]