XB-FEAT-993434

chchd2

This is the community wiki page for the gene chchd2 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.

nomenclature changes

06FEB2025

following advice fron RefSeq: RSCOM-685

XB-GENE-993435 (Gene Symbol: gpat3; Gene Name: glycerol-3-phosphate acyltransferase 3) is associated with GeneID 493261. This nomenclature belongs on GeneID 100485787. GeneID 493261 is the ortholog of human GeneID 51142, CHCHD2, coiled-coil-helix-coiled-coil-helix domain-containing protein 2. Please update the nomenclature for both XB IDs.

This Xenopus tropicalis gene model has been remanmed chchd2, coiled-coil-helix-coiled-coil-helix domain-containing 2, and gpat3 is now associated with XB-GENE-29077995, GeneID 100485787, which is the ortholog of human GeneID 84803, GPAT3.

Orthologs and synonyms have been updated ( swapped) between gene pages as well.

summary for CHCHD2 from NCBI

The protein encoded by this gene belongs to a class of eukaryotic CX(9)C proteins characterized by four cysteine residues spaced ten amino acids apart from one another. These residues form disulfide linkages that define a CHCH fold. In response to stress, the protein translocates from the mitochondrial intermembrane space to the nucleus where it binds to a highly conserved 13 nucleotide oxygen responsive element in the promoter of cytochrome oxidase 4I2, a subunit of the terminal enzyme of the electron transport chain. In concert with recombination signal sequence-binding protein J, binding of this protein activates the oxygen responsive element at four percent oxygen. In addition, it has been shown that this protein is a negative regulator of mitochondria-mediated apoptosis. In response to apoptotic stimuli, mitochondrial levels of this protein decrease, allowing BCL2-associated X protein to oligomerize and activate the caspase cascade. Pseudogenes of this gene are found on multiple chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]