BMS-453

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Description

Synthetic retinoid. Retinoic acid receptor β (RARβ) agonist in vivo; RARα and RARγ antagonist in vitro. Inhibits breast cell proliferation by inducing active transforming growth factor β (TGFβ) and causes G1 arrest.

Bms 453 structure, image from NCBI Pubchem

Alternative Name

BMS 189453

Chemical Name

4-[(1E)-2-(5,6-Dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl)ethenyl]-benzoic acid

Suppliers

Tocris

References

Using frogs faces to dissect the mechanisms underlying human orofacial defects. Dickinson AJ. Semin Cell Dev Biol. March 1, 2016; 51 54-63.
Median facial clefts in Xenopus laevis: roles of retinoic acid signaling and homeobox genes. Kennedy AE, Dickinson AJ. Dev Biol. May 1, 2012; 365 (1): 229-40.
National Center for Biotechnology Information. PubChem Compound Database; CID=9875424, [1]