XB-FEAT-966740

birc5

This is the community wiki page for the gene birc5 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.

nomenclature changes

05FEB2025

Following assessment by RefSeq Communications. RSCOM-687 We have Swap nomenclature for XB-GENE-966741 (birc5l) and XB-GENE-5850943 (birc5):

XB-GENE-966741 is associated with GeneID 733575, which is the ortholog of human GeneID 332, BIRC5. It has been renamed changing from birc5l to birc5.

XB-GENE-5850943 is associated with GeneID 733532. It has been changed from birc5 to birc5l.

summary from NCBI for human BIRC5

BIRC5 - baculoviral IAP repeat containing 5

This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2011]