XB-FEAT-992988

brms1

This is the community wiki page for the gene brms1 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.

summary from NCBI

This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines. The protein encoded by this gene localizes primarily to the nucleus and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

nomenclature issues

05.14.2018 Human name has changed for Entrez Gene: 25855. From breast cancer metastasis suppressor 1 to BRMS1, transcriptional repressor and anoikis regulator