XB-FEAT-478880

c4a

This is the community wiki page for the gene c4a please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase

nomenclature changes

2.26.20

name changed from 'complement component 4A (Rodgers blood group)' to 'complement C4A (Rodgers blood group)', following human nomenclature.

Summary for human C4A from NCBI

This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain is cleaved to release C4 anaphylatoxin, an antimicrobial peptide and a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]