XB-FEAT-5894897

c7

This is the community wiki page for the gene c7 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase

nomenclature changes

02.25.20

gene name changed from 'complement component 7' to 'complement C7', following human gene nomenclature.

Summary for human C& from NCBI

This gene encodes a serum glycoprotein that forms a membrane attack complex together with complement components C5b, C6, C8, and C9 as part of the terminal complement pathway of the innate immune system. The protein encoded by this gene contains a cholesterol-dependent cytolysin/membrane attack complex/perforin-like (CDC/MACPF) domain and belongs to a large family of structurally related molecules that form pores involved in host immunity and bacterial pathogenesis. This protein initiates membrane attack complex formation by binding the C5b-C6 subcomplex and inserts into the phospholipid bilayer, serving as a membrane anchor. Mutations in this gene are associated with a rare disorder called C7 deficiency. [provided by RefSeq, Nov 2016]