XB-FEAT-949743

tcim

This is the community wiki page for the gene tcim please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase

nomenclature changes

08/15/2017 Human symbol has changed for genepage ID: 949743 From c8orf4 to tcim

Human symbol has changed for Entrez Gene: 56892. From C8orf4 to TCIM

Human name has changed for Entrez Gene: 56892. From chromosome 8 open reading frame 4 to transcriptional and immune response regulator

summary from NCBI

This gene encodes a small, monomeric, predominantly unstructured protein that functions as a positive regulator of the Wnt/beta-catenin signaling pathway. This protein interacts with a repressor of beta-catenin mediated transcription at nuclear speckles. It is thought to competitively block interactions of the repressor with beta-catenin, resulting in up-regulation of beta-catenin target genes. The encoded protein may also play a role in the NF-kappaB and ERK1/2 signaling pathways. Expression of this gene may play a role in the proliferation of several types of cancer including thyroid cancer, breast cancer and hematological malignancies. [provided by RefSeq, Nov 2011]