XB-FEAT-992706

ca13

This is the community wiki page for the gene ca13 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.

nomenclature changes

22 June 2023

Xenopus gene name changed from carbonic anhydrase XIII to carbonic anhydrase 13 gene 1

This name update is because a) the human name has changed from using roman numerals to arabic numerals, and b) a duplicated ca13 genes was identified in X. tropicalis and X.laevis on chromosomes 6/6L/6S. This was supported by synteny, protein alignment and phlogenetic trees of all of the 'ca' genes in this arm of Chr6/6L/6S

Subsequently ca13.1 is added as as synonym.

A new gene page is being created fro these ca13.2 genes

synteny

Xtr chr6: e2f5> rbis< car1_p(ca13.2)> ca13> ca1< ca3> ca2> ... pskh2<

Xla.Chr6L: e2f5.L> rbis.L< LOC108719319(ca13.2.L)> ca13.L> ca1.L< ca3.L> ca2.L> ... LOC108719321(pskh2.L)<

Xla.Chr6S: e2f5.S> rbis.S< LOC496283(ca13.2.S)> LOC108719741(ca13.S)> ca2.S> pskh2.S>

Human: E2F5> RBIS< CA13> CA1< CA3< CA2> PSKH2>

The following proteins accessions for the X. tropicalis and 'X. laevis ca gens were used to determine the relationship between genes/species and that the 'new' gene was a duplicate of ca13, as opposed to a novel 'ca' gene' or a duplicate of one of the othehr 'ca' genes in this cluster.

ref|NP_001072785.1| ref|NP_001072448.1| ref|XP_002939197.2| ref|XP_012820094.1| ref|XP_002939198.1| ref|XP_017950194.1| ref|XP_041422471.1| ref|NP_001088912.1| ref|XP_018124394.1| ref|NP_001079371.1| ref|NP_001086981.1| ref|XP_018122409.1| ref|XP_018123594.1| ref|NP_001080080.1|