XB-FEAT-980594

fbh1

This is the community wiki page for the gene fbh1 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.

nomenclature changes

02/12/2018 Human symbol has changed for genepage ID: 980594 From fbxo18 to fbh1

Human symbol has changed for Entrez Gene: 84893. From FBXO18 to FBH1

Human name has changed for Entrez Gene: 84893. From F-box protein, helicase, 18 to F-box DNA helicase 1

Summary from NCBI

This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbx class. It contains an F-box motif and seven conserved helicase motifs, and has both DNA-dependent ATPase and DNA unwinding activities. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]