XB-FEAT-478209

fzd4

This is the community wiki page for the gene fzd4 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase

gene function and expression notes

source: Maja Gere and Tomas Pieler (University Gottingen, Germany), talk given at EAC , Rennes, July 30th, 2017.

hnf1b and fzd4 have been identified as RA-induced genes responsible for pancreas specification.

fzd4 is required for pancreas development, and likely negatively regulates wnt signalling to allow pancreas progenitor differentiation.

summary from NCBI

This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This protein may play a role as a positive regulator of the Wingless type MMTV integration site signaling pathway. A transcript variant retaining intronic sequence and encoding a shorter isoform has been described, however, its expression is not supported by other experimental evidence. [provided by RefSeq, Jul 2008]