XB-FEAT-5867414

gnrhr2

This is the community wiki page for the gene gnrhr2 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase

summary from NCBI for human GNRHR2

In non-hominoid primates and non-mammalian vertebrates, the gonadotropin releasing hormone 2 receptor gene (GnRHR2) encodes a seven-transmembrane G-protein coupled receptor. However, in human, the corresponding reading frame contains a premature stop codon, which has been suggested to encode a selenocysteine residue, but there is no solid evidence for selenocysteine incorporation (PMID: 12538601). It appears that the human GnRHR2 transcription occurs but the gene does not likely produce a functional multi-transmembrane protein. A non-transcribed pseudogene of GnRHR2 is located on chromosome 14. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2013].

nomenclature changes

3/4/2022

removed ‘pseudogene’ from gene name, as only human gene is thought to be non-functional.