XB-FEAT-855696

ifnl3

This is the community wiki page for the gene ifnl3 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase

nomenclature changes

12May2023

Following human gen ename update, Xenopus gene name changed from il28b.1, interleukin 28B (interferon, lambda 3), gene 1 to ifnl3, interferon lambda 3.

il28b and il28b.1 are recorded as legacy gene symbols

summary for human IFNL3 from NCBI

This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq, Jul 2008]