XB-FEAT-5886631

myzap

This is the community wiki page for the gene myzap please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase

nomenclature changes

1/6/15 Human symbol has changed for genepage ID: 5886631 From myzap to GCOM1

2/2/15 Human symbol has changed for genepage ID: 5886631 From gcom1 to MYZAP

curators notes:

this gene, [ myzap] links to 2 human genes [MYZAP and GCOM1] because gcom1 is kind of special- see the NCBI summaries below

Summary from NCBI for MYZAP

This gene encodes a protein that is abundantly expressed in cardiac tissue. The encoded protein localizes to intercalated discs in cardiomyocytes and functions as an activator of Rho-dependent serum-response factor signaling. Alternative splicing results in multiple transcript variants. Readthrough transcription also exists between this gene and the neighboring downstream gene POLR2M (polymerase (RNA) II (DNA directed) polypeptide M) and is represented with GeneID: 145781. [provided by RefSeq, Mar 2014]

Summary from NCBI for GCOM1

 This locus represents naturally occurring readthrough transcription between the neighboring MYZAP (myocardial zonula adherens protein) and POLR2M (polymerase (RNA) II (DNA directed) polypeptide M) genes on chromosome 15. Alternative splicing results in multiple readthrough transcript variants. Readthrough variants may encode proteins that share sequence identity with the upstream gene product or with both the upstream and downstream gene products. Some readthrough transcript variants are also expected to be candidates for nonsense-mediated decay (NMD). [provided by RefSeq, Oct 2013]