XB-FEAT-876755

nfatc1

This is the community wiki page for the gene nfatc1 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase

nomenclature changes

04/22/ 2016

Human name has changed for Entrez Gene: 4772. From nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 to nuclear factor of activated T-cells 1

12/18/2017 Human name has changed for Entrez Gene: 4772. From nuclear factor of activated T-cells 1 to nuclear factor of activated T cells 1

NCBI Summary

The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes. [provided by RefSeq, Jul 2013]