XB-FEAT-943925

nfe2l2

This is the community wiki page for the gene nfe2l2 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.

nomenclature changes

01/12/2016 Human name has changed for Entrez Gene: 4780. From nuclear factor, erythroid 2-like 2 to nuclear factor, erythroid 2 like 2.

10.20.2021 Human name has changed for Entrez Gene: 4780. From nuclear factor, erythroid 2 like 2 to NFE2 like bZIP transcription factor 2

human symbol NFE2L2 is unchanged, although we expect it will be updated to remove the L for like.

summary for human NFE2L2 from NCBI

This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been characterized for this gene. [provided by RefSeq, Sep 2015]