XB-FEAT-962622

nsun2

This is the community wiki page for the gene nsun2 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.

nomenclature changes

05.13.19 Human name has changed for Entrez Gene: 54888. From NOP2/Sun RNA methyltransferase family member 2 to NOP2/Sun RNA methyltransferase 2

Summary from NCBI for human NSUN2

This gene encodes a methyltransferase that catalyzes the methylation of cytosine to 5-methylcytosine (m5C) at position 34 of intron-containing tRNA(Leu)(CAA) precursors. This modification is necessary to stabilize the anticodon-codon pairing and correctly translate the mRNA. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Mar 2011]