XB-FEAT-1008530

ptprk

This is the community wiki page for the gene ptprk please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.

nomenclature changes

01/12/2016

Human name has changed for Entrez Gene: 5796. From protein tyrosine phosphatase, receptor type, K to protein tyrosine phosphatase, receptor type K.

05.13.19

Human name has changed for Entrez Gene: 5796. From protein tyrosine phosphatase, receptor type K to protein tyrosine phosphatase receptor type K

Summary from NCBI for human PTPRK

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP was shown to mediate homophilic intercellular interaction, possibly through the interaction with beta- and gamma-catenin at adherens junctions. Expression of this gene was found to be stimulated by TGF-beta 1, which may be important for the inhibition of keratinocyte proliferation. [provided by RefSeq, Jul 2008]