XB-FEAT-922687

ptpru

This is the community wiki page for the gene ptpru please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.

Summary from NCBI, human PTPRU

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. This PTP was thought to play roles in cell-cell recognition and adhesion. Studies of the similar gene in mice suggested the role of this PTP in early neural development. The expression of this gene was reported to be regulated by phorbol myristate acetate (PMA) or calcium ionophore in Jurkat T lymphoma cells. Alternatively spliced transcript variants have been reported. [provided by RefSeq, Aug 2010]

nomenlcature changes

05.13.19 Human name has changed for Entrez Gene: 10076. From protein tyrosine phosphatase, receptor type, U to protein tyrosine phosphatase receptor type U