R-roscovitine: Difference between revisions
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imported>Xenbase (Created page with "==Description== "R-roscovitine is a cyclin-dependent kinase (CDK) inhibitor that induces apoptosis in colorectal, breast, prostate, multiple myeloma, other cancer cell lines,...") |
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"R-roscovitine is a cyclin-dependent kinase (CDK) inhibitor that induces apoptosis in colorectal, breast, prostate, multiple myeloma, other cancer cell lines, and tumor xenografts, in micromolar concentrations. R-roscovitine also blocks voltage-gated K+channels by binding to the open state." "R-roscovitine inhibits open hERG channels but does not become trapped in the pore." | "R-roscovitine is a cyclin-dependent kinase (CDK) inhibitor that induces apoptosis in colorectal, breast, prostate, multiple myeloma, other cancer cell lines, and tumor xenografts, in micromolar concentrations. R-roscovitine also blocks voltage-gated K+channels by binding to the open state." "R-roscovitine inhibits open hERG channels but does not become trapped in the pore." | ||
Source: | Source: Cernuda B, Fernandes CT, Allam SM, Orzillo M, Suppa G, Chia Chang Z, et al. (2019) The molecular determinants of R-roscovitine block of hERG channels. PLoS ONE 14(9): e0217733. https://doi.org/10.1371/journal.pone.0217733 | ||
Cernuda B, Fernandes CT, Allam SM, Orzillo M, Suppa G, Chia Chang Z, et al. (2019) The molecular determinants of R-roscovitine block of hERG channels. PLoS ONE 14(9): e0217733. https://doi.org/10.1371/journal.pone.0217733 | |||
Latest revision as of 06:27, 12 September 2019
Description
"R-roscovitine is a cyclin-dependent kinase (CDK) inhibitor that induces apoptosis in colorectal, breast, prostate, multiple myeloma, other cancer cell lines, and tumor xenografts, in micromolar concentrations. R-roscovitine also blocks voltage-gated K+channels by binding to the open state." "R-roscovitine inhibits open hERG channels but does not become trapped in the pore."
Source: Cernuda B, Fernandes CT, Allam SM, Orzillo M, Suppa G, Chia Chang Z, et al. (2019) The molecular determinants of R-roscovitine block of hERG channels. PLoS ONE 14(9): e0217733. https://doi.org/10.1371/journal.pone.0217733