https://wiki.xenbase.org/xenwiki/index.php?title=R-roscovitine&feed=atom&action=history
R-roscovitine - Revision history
2024-03-28T17:36:32Z
Revision history for this page on the wiki
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https://wiki.xenbase.org/xenwiki/index.php?title=R-roscovitine&diff=48972&oldid=prev
imported>Xenbase: /* Description */
2019-09-12T12:27:42Z
<p><span dir="auto"><span class="autocomment">Description</span></span></p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 06:27, 12 September 2019</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Description==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Description==</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>"R-roscovitine is a cyclin-dependent kinase (CDK) inhibitor that induces apoptosis in colorectal, breast, prostate, multiple myeloma, other cancer cell lines, and tumor xenografts, in micromolar concentrations. R-roscovitine also blocks voltage-gated K+channels by binding to the open state." "R-roscovitine inhibits open hERG channels but does not become trapped in the pore." </div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>"R-roscovitine is a cyclin-dependent kinase (CDK) inhibitor that induces apoptosis in colorectal, breast, prostate, multiple myeloma, other cancer cell lines, and tumor xenografts, in micromolar concentrations. R-roscovitine also blocks voltage-gated K+channels by binding to the open state." "R-roscovitine inhibits open hERG channels but does not become trapped in the pore." </div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Source: Cernuda B, Fernandes CT, Allam SM, Orzillo M, Suppa G, Chia Chang Z, et al. (2019) The molecular determinants of R-roscovitine block of hERG channels. PLoS ONE 14(9): e0217733. https://doi.org/10.1371/journal.pone.0217733</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Source: Cernuda B, Fernandes CT, Allam SM, Orzillo M, Suppa G, Chia Chang Z, et al. (2019) The molecular determinants of R-roscovitine block of hERG channels. PLoS ONE 14(9): e0217733. https://doi.org/10.1371/journal.pone.0217733</div></td></tr>
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imported>Xenbase
https://wiki.xenbase.org/xenwiki/index.php?title=R-roscovitine&diff=48971&oldid=prev
imported>Xenbase at 12:27, 12 September 2019
2019-09-12T12:27:31Z
<p></p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 06:27, 12 September 2019</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Description==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Description==</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>"R-roscovitine is a cyclin-dependent kinase (CDK) inhibitor that induces apoptosis in colorectal, breast, prostate, multiple myeloma, other cancer cell lines, and tumor xenografts, in micromolar concentrations. R-roscovitine also blocks voltage-gated K+channels by binding to the open state." "R-roscovitine inhibits open hERG channels but does not become trapped in the pore." </div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>"R-roscovitine is a cyclin-dependent kinase (CDK) inhibitor that induces apoptosis in colorectal, breast, prostate, multiple myeloma, other cancer cell lines, and tumor xenografts, in micromolar concentrations. R-roscovitine also blocks voltage-gated K+channels by binding to the open state." "R-roscovitine inhibits open hERG channels but does not become trapped in the pore." </div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> </div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Source: Cernuda B, Fernandes CT, Allam SM, Orzillo M, Suppa G, Chia Chang Z, et al. (2019) The molecular determinants of R-roscovitine block of hERG channels. PLoS ONE 14(9): e0217733. https://doi.org/10.1371/journal.pone.0217733</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Source: </div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> </div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Cernuda B, Fernandes CT, Allam SM, Orzillo M, Suppa G, Chia Chang Z, et al. (2019) The molecular determinants of R-roscovitine block of hERG channels. PLoS ONE 14(9): e0217733. https://doi.org/10.1371/journal.pone.0217733</div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> </div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> </div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">[[File:Olomoucine.png|frame|right|Olomoucine structure, photo from Sigma-Aldrich]]</del></div></td><td colspan="2" class="diff-side-added"></td></tr>
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imported>Xenbase
https://wiki.xenbase.org/xenwiki/index.php?title=R-roscovitine&diff=48970&oldid=prev
imported>Xenbase: Created page with "==Description== "R-roscovitine is a cyclin-dependent kinase (CDK) inhibitor that induces apoptosis in colorectal, breast, prostate, multiple myeloma, other cancer cell lines,..."
2019-09-12T12:26:01Z
<p>Created page with "==Description== "R-roscovitine is a cyclin-dependent kinase (CDK) inhibitor that induces apoptosis in colorectal, breast, prostate, multiple myeloma, other cancer cell lines,..."</p>
<p><b>New page</b></p><div>==Description==<br />
"R-roscovitine is a cyclin-dependent kinase (CDK) inhibitor that induces apoptosis in colorectal, breast, prostate, multiple myeloma, other cancer cell lines, and tumor xenografts, in micromolar concentrations. R-roscovitine also blocks voltage-gated K+channels by binding to the open state." "R-roscovitine inhibits open hERG channels but does not become trapped in the pore." <br />
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Source: <br />
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Cernuda B, Fernandes CT, Allam SM, Orzillo M, Suppa G, Chia Chang Z, et al. (2019) The molecular determinants of R-roscovitine block of hERG channels. PLoS ONE 14(9): e0217733. https://doi.org/10.1371/journal.pone.0217733<br />
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[[File:Olomoucine.png|frame|right|Olomoucine structure, photo from Sigma-Aldrich]]</div>
imported>Xenbase