XB-FEAT-5852261

cradd

This is the community wiki page for the gene cradd please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase

Summary fro human CRADD from NCBI

CRADD - CASP2 and RIPK1 domain containing adaptor with death domain

This gene encodes a protein containing a death domain (DD) motif. This protein recruits caspase 2/ICH1 to the cell death signal transduction complex, which includes tumor necrosis factor receptor 1 (TNFR1A) and RIPK1/RIP kinase, and acts in promoting apoptosis. A mutation in this gene was associated with cognitive disability.