SB431542: Difference between revisions

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imported>Kevin
(Created page with "==Genes Affected== *[http://www.xenbase.org/gene/showgene.do?method=displayGeneSummary&geneId=483903 ALK4 is a synonym for acvr1b] *[http://www.xenbase.org/gene/showgene.do?me...")
 
imported>Xenbase
m (Xenbase moved page SB-431542 to SB431542: Consolidating duplicates)
 
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==Description==
"Potent and selective inhibitor of the transforming growth factor-β (TGF-β) type I receptor activin receptor-like kinase ALK5 (IC50 = 94 nM), and its relatives ALK4 and ALK7. Suppresses TGF-β-induced proliferation of human osteosarcoma cells. Stimulates proliferation, differentiation and sheet formation of ESC-derived endothelial cells."
*-Tocris Product Description
[[File:SB431542.png|frame|right|SB-431542 structure, photo from Sigma-Aldrich]]
==Genes Affected==
==Genes Affected==
*[http://www.xenbase.org/gene/showgene.do?method=displayGeneSummary&geneId=483903 ALK4 is a synonym for acvr1b]
*[http://www.xenbase.org/gene/showgene.do?method=displayGeneSummary&geneId=483903 ALK4 is a synonym for acvr1b]
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*[http://www.selleckchem.com/products/SB-431542.html Selleckchem]
*[http://www.selleckchem.com/products/SB-431542.html Selleckchem]


==references==
==Usage Notes==
 
==References==
*[http://www.xenbase.org/literature/article.do?method=display&articleId=371 Ho et al., 2006]
*[http://www.xenbase.org/literature/article.do?method=display&articleId=371 Ho et al., 2006]
* >23 other references within Xenbase use SB-431542 according to [http://www.xenbase.org/cgi-bin/textpresso/xenopus/search Textpresso]
*[http://www.xenbase.org/literature/article.do?method=display&articleId=49634 Chiu 2014]
*[http://www.xenbase.org/literature/article.do?method=display&articleId=54570 Sato et al 2018]
*[https://pubchem.ncbi.nlm.nih.gov/compound/4521392 NCBI PubChem CID:4521392]
 
> 40 Xenbase articles contain a reference to SB431542 according to [http://www.xenbase.org/cgi-bin/textpresso/xenopus/search textpresso]
*
*[[Small Molecules for Xenopus Research|Back To Small Molecules Home Page]]

Latest revision as of 13:19, 9 April 2018

Description

"Potent and selective inhibitor of the transforming growth factor-β (TGF-β) type I receptor activin receptor-like kinase ALK5 (IC50 = 94 nM), and its relatives ALK4 and ALK7. Suppresses TGF-β-induced proliferation of human osteosarcoma cells. Stimulates proliferation, differentiation and sheet formation of ESC-derived endothelial cells."

  • -Tocris Product Description
SB-431542 structure, photo from Sigma-Aldrich

Genes Affected

Suppliers

Usage Notes

References

> 40 Xenbase articles contain a reference to SB431542 according to textpresso