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"Potent and selective inhibitor of the transforming growth factor-β (TGF-β) type I receptor activin receptor-like kinase ALK5 (IC50 = 94 nM), and its relatives ALK4 and ALK7. Suppresses TGF-β-induced proliferation of human osteosarcoma cells. Stimulates proliferation, differentiation and sheet formation of ESC-derived endothelial cells."

  • -Tocris Product Description
SB-431542 structure, photo from Sigma-Aldrich

Genes Affected


Usage Notes


> 40 Xenbase articles contain a reference to SB431542 according to textpresso