XB-FEAT-5861248

sephs3

This is the community wiki page for the gene sephs3 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase

=summary for Xenopus sephs3 from NCBI+ This gene encodes an enzyme that catalyzes the production of monoselenophosphate (MSP) from selenide and ATP. MSP is the selenium donor required for synthesis of selenocysteine (Sec), which is co-translationally incorporated into selenoproteins at in-frame UGA codons that normally signal translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is itself a selenoprotein containing a Sec residue at its active site, suggesting the existence of an autoregulatory mechanism. It is preferentially expressed in tissues implicated in the synthesis of selenoproteins and in sites of blood cell development. [provided by RefSeq, May 2017]

nomenclature changes

On November 7, 2019, this genepage was renamed from sephs2 to sephs3.

This ancestral gene was a multi-exon gene that has a single-exon retrocopy that has persisted to mammals, while the multi-exon ancestral gene was lost.

In humans, the single-exon gene is SEPHS2. As such, this Xenopus gene was determined to be sephs3, the next gene number in the SEPHS family.

PMID:22479358 describes a bit of the evolutionary history.

Note: do not change back to sephs2 unless directed to do so by RefSeq/NCBI or the HGNC