XB-FEAT-485651

hnf1b

This is the community wiki page for the gene hnf1b please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase

gene functionnand expression notes

source: Maja Gere and Tomas Pieler talk, EAC July 30th, 2017.

hnf1b and fzd4 have been identified as RA-induced genes responsible for pancreas specification.

hnf1b expressed in entire endoderm at Stage 10.5, and is required for pancreas development.

overexpression of hnf1b leads to an expansion of pancreas progentior field at NF stage 28 to 32.

summary from NCBI

This gene encodes a member of the homeodomain-containing superfamily of transcription factors. The protein binds to DNA as either a homodimer, or a heterodimer with the related protein hepatocyte nuclear factor 1-alpha. The gene has been shown to function in nephron development, and regulates development of the embryonic pancreas. Mutations in this gene result in renal cysts and diabetes syndrome and noninsulin-dependent diabetes mellitus, and expression of this gene is altered in some types of cancer. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]