XB-FEAT-6065253

prss2

This is the community wiki page for the gene prss2 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase

Summary from NCBI

This gene belongs to the trypsin family of serine proteases and encodes anionic trypsinogen. It is part of a cluster of trypsinogen genes that are located within the T cell receptor beta locus. Enzymes of this family cleave peptide bonds that follow lysine or arginine residues. This protein is found at high levels in pancreatic juice and its upregulation is a characteristic feature of pancreatitis. This protein has also been found to activate pro-urokinase in ovarian tumors, suggesting a function in tumor invasion. In addition, this enzyme is able to cleave across the type II collagen triple helix in rheumatoid arthritis synovitis tissue, potentially participating in the degradation of type II collagen-rich cartilage matrix. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2015].

nomenclature changes

01/22/2018 Human name has changed for Entrez Gene: 5645. From protease, serine 2 to serine protease 2