XB-FEAT-5788468

tuba5

This is the community wiki page for the gene tuba5 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase

nomenclature changes

03.30.2020

gene symbol changed from tuba3c to tuba5

gene name changed from tubulin alpha 3, subunit c to tubulin alpha 5

It is NOT orthologous to to human TUBA3C, and that link was removed from the Xenbase genepage.

Background: from David Webb at NCBI/ref Seq. March, 2020.

This is a protein-coding alpha tubulin gene, that's conserved going back at least to the origin of Osteichthyes. It has been pseudogenized within placental mammals (ie called TUBA5P). HGNC refered to it as TUBAP5 (HGNC: 54799). ZFIN called it tuba8l (ZDB-GENE-030131-9167) and Xenbase calls it tuba3c (XB-GENE-5788469).

It invariably resides in this gene order: CYB5R1>...ADIPOR1>...KHL12>...RABIF>...tuba5>...MGAT4E<...KDM5B>

In Xenopus, tuba5 is on chromosome 2, and usually encodes a 449aa protein.

DW could not determine where this gene became a pseudogene in mammals. Platypus and opossum clearly conserve the 449 codons as well as aardvark, cat, tree shrew, and lemurs. Some rodents like Marmota and Ictidomys plausibly encode 449 aa but it's clearly a pseudogene in human, mouse and rat and is likely a pseudogene in cow, pig and horse too. After discussion across gene nomenclature committees, the HGNC agreed to call the protein coding gene 'TUBA5', and the psuedogene in human 'TUBA5P'.

orthologs have been updated:Human- TUBA5P – tubulin alpha 5, pseudogene, Gene ID: 730222.