XB-FEAT-6457635

uqcrb

This is the community wiki page for the gene uqcrb please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.

gene nomenclature updates

18NOV2024 Xenopus gene name and symbol was updated, from LOC101732809 , cytochrome b-c1 complex subunit 7 to uqcrb - ubiquinol-cytochrome c reductase binding protein.

summary for human UQCRB from NCBI

This gene encodes a subunit of the ubiquinol-cytochrome c oxidoreductase complex, which consists of one mitochondrial-encoded and 10 nuclear-encoded subunits. The protein encoded by this gene binds ubiquinone and participates in the transfer of electrons when ubiquinone is bound. This protein plays an important role in hypoxia-induced angiogenesis through mitochondrial reactive oxygen species-mediated signaling. Mutations in this gene are associated with mitochondrial complex III deficiency. Alternatively spliced transcript variants have been found for this gene. Related pseudogenes have been identified on chromosomes 1, 5 and X. [provided by RefSeq, Dec 2011]