Vismodegib: Difference between revisions

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= Vismodegib=
Supplier: MedChem Express; catalog # HY-10440 "Vismodegib is an orally active hedgehog pathway inhibitor with an IC50 of 3 nM and also inhibits P-gp, ABCG2 with IC50 values of 3.0 μM and 1.4 μM, respectively."
Supplier: MedChem Express; catalog # HY-10440


Function: Shh (sonic hedgehog) signal pathway antagonist. Vismodegib treatment to tapdpoles alters the development of the ear, hypaxial muscle, and indirectly, the Mauthner cells, through its interaction with the inner ear afferents. (ref PMID: 29030893)
Function: Shh (sonic hedgehog) signal pathway inhibitor.  
 
Phenotypic Effect: Vismodegib treatment of tapdpoles alters the development of the ear, hypaxial muscle, and indirectly, the Mauthner cells, through its interaction with the inner ear afferents. (ref PMID: 29030893)
 
PubChem CID: 24776445
 
Molecular Formula: C19H14Cl2N2O3S
 
Molecular Weight: 421.292 g/mol
 
InChI Key: BPQMGSKTAYIVFO-UHFFFAOYSA-N
 
Synonyms: 879085-55-9; GDC-0449; Erivedge; 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide

Latest revision as of 15:15, 20 January 2021

Supplier: MedChem Express; catalog # HY-10440 "Vismodegib is an orally active hedgehog pathway inhibitor with an IC50 of 3 nM and also inhibits P-gp, ABCG2 with IC50 values of 3.0 μM and 1.4 μM, respectively."

Function: Shh (sonic hedgehog) signal pathway inhibitor.

Phenotypic Effect: Vismodegib treatment of tapdpoles alters the development of the ear, hypaxial muscle, and indirectly, the Mauthner cells, through its interaction with the inner ear afferents. (ref PMID: 29030893)

PubChem CID: 24776445

Molecular Formula: C19H14Cl2N2O3S

Molecular Weight: 421.292 g/mol

InChI Key: BPQMGSKTAYIVFO-UHFFFAOYSA-N

Synonyms: 879085-55-9; GDC-0449; Erivedge; 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide