XB-FEAT-29085838

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adam33

This is the community wiki page for the gene adam33 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.

nomenclature changes

13SEPT2023

Following a review by Xenbase and the NCBIref seq team, the Xenopus gene name has changed from LOC101732075, disintegrin and metalloproteinase domain-containing protein 12' to adam33, ADAM metallopeptidase domain 33

By synteny, the true Xtropicalis ortholog of human ADAM33 is Xenopus GeneID: 101732075 (XB-GENE-29085839) along with X. laevis.L GeneID: 108697349 & X. laevis.S & GeneID: 108704093.

summary for HUMAN ADAM33 from NCBI

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This protein is a type I transmembrane protein implicated in asthma and bronchial hyperresponsiveness. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2013]

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