XB-FEAT-485651: Difference between revisions
imported>Xenbase gene generator No edit summary |
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=hnf1b= | =hnf1b= | ||
This is the community wiki page for the gene ''hnf1b'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase | This is the community wiki page for the gene ''hnf1b'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase | ||
=gene functionnand expression notes= | |||
source: Maja Gere and Tomas Pieler talk, EAC July 30th, 2017. | |||
hnf1b and fzd4 have been identified as RA-induced genes responsible for pancreas specification. | |||
=summary from NCBI= | |||
This gene encodes a member of the homeodomain-containing superfamily of transcription factors. The protein binds to DNA as either a homodimer, or a heterodimer with the related protein hepatocyte nuclear factor 1-alpha. The gene has been shown to function in nephron development, and regulates development of the embryonic pancreas. Mutations in this gene result in renal cysts and diabetes syndrome and noninsulin-dependent diabetes mellitus, and expression of this gene is altered in some types of cancer. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009] | |||
Revision as of 03:45, 30 June 2017
hnf1b
This is the community wiki page for the gene hnf1b please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase
gene functionnand expression notes
source: Maja Gere and Tomas Pieler talk, EAC July 30th, 2017.
hnf1b and fzd4 have been identified as RA-induced genes responsible for pancreas specification.
summary from NCBI
This gene encodes a member of the homeodomain-containing superfamily of transcription factors. The protein binds to DNA as either a homodimer, or a heterodimer with the related protein hepatocyte nuclear factor 1-alpha. The gene has been shown to function in nephron development, and regulates development of the embryonic pancreas. Mutations in this gene result in renal cysts and diabetes syndrome and noninsulin-dependent diabetes mellitus, and expression of this gene is altered in some types of cancer. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]