XB-FEAT-5848002: Difference between revisions
imported>Xenbase (→loc100494211: Updated nomenclature, replaced: unnamed → loc100494211 (2)) |
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This is the community wiki page for the gene ''loc100494211'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase | This is the community wiki page for the gene ''loc100494211'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase. | ||
=synonym= | |||
loc100494211 referred to as 'Bighead' in this article. XB-ART-55302 | |||
Bighead is a Wnt antagonist secreted by the Xenopus Spemann organizer that promotes Lrp6 endocytosis | |||
Yi Ding, Gabriele Colozza, Eric A. Sosa, Yuki Moriyama, Samantha Rundle, Lukasz Salwinski, and Edward M. De Robertis | |||
PNAS published ahead of print September 12, 2018 https://doi.org/10.1073/pnas.1812117115. | |||
=protein function and phenotype notes= | |||
Bighead is a secreted protein that inhibits Wnt by causing the endocytosis and degradation in lysosomes of the Wnt coreceptor Lrp6. | |||
Its overexpression induces embryos with larger heads, and its knockdown reduces head development through the regulation of Wnt signaling. | |||
source: | |||
Bighead is a Wnt antagonist secreted by the Xenopus Spemann organizer that promotes Lrp6 endocytosis | |||
Yi Ding, Gabriele Colozza, Eric A. Sosa, Yuki Moriyama, Samantha Rundle, Lukasz Salwinski, and Edward M. De Robertis | |||
PNAS published ahead of print September 12, 2018 https://doi.org/10.1073/pnas.1812117115. | |||
Revision as of 10:15, 21 September 2018
loc100494211
This is the community wiki page for the gene loc100494211 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.
synonym
loc100494211 referred to as 'Bighead' in this article. XB-ART-55302 Bighead is a Wnt antagonist secreted by the Xenopus Spemann organizer that promotes Lrp6 endocytosis Yi Ding, Gabriele Colozza, Eric A. Sosa, Yuki Moriyama, Samantha Rundle, Lukasz Salwinski, and Edward M. De Robertis PNAS published ahead of print September 12, 2018 https://doi.org/10.1073/pnas.1812117115.
protein function and phenotype notes
Bighead is a secreted protein that inhibits Wnt by causing the endocytosis and degradation in lysosomes of the Wnt coreceptor Lrp6. Its overexpression induces embryos with larger heads, and its knockdown reduces head development through the regulation of Wnt signaling.
source: Bighead is a Wnt antagonist secreted by the Xenopus Spemann organizer that promotes Lrp6 endocytosis Yi Ding, Gabriele Colozza, Eric A. Sosa, Yuki Moriyama, Samantha Rundle, Lukasz Salwinski, and Edward M. De Robertis PNAS published ahead of print September 12, 2018 https://doi.org/10.1073/pnas.1812117115.