XB-FEAT-5861248

sephs3

This is the community wiki page for the gene sephs3 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase

nomenclature changes

On November 7, 2019, this genepage was renamed from sephs2 to sephs3.

This ancestral gene was a multi-exon gene that has a single-exon retrocopy that has persisted to mammals, while the multi-exon ancestral gene was lost.

In humans, the single-exon gene is SEPHS2. As such, this Xenopus gene was determined to be sephs3, the next gene number in the SEPHS family.

PMID:22479358 describes a bit of the evolutionary history.

Note: do not change back to sephs2 unless directed to do so by RefSeq/NCBI or the HGNC